Pulsed electric field ablation (PFA) is an emerging ablation therapy based on the principle of non-thermal irreversible electroporation (IRE), in which a high-voltage pulsed electric field is applied to cardiomyocytes to form irreversible nanoscale perforations in the cell membrane, resulting in cell death due to elevated cell permeability and thus tissue ablation is achieved.PFA, with the advantages of tissue selectivity, non-thermal ablation, and high ablation efficiency, has been globally It has been gradually developed.

Unlike traditional thermal-based ablation methods, PFA selectively ablates cardiac tissue, preserving blood vessels, nerves, and other pericardial tissues. Pulsed electric field ablation is considered to be the next generation of cardiac electrophysiologic ablation because of its high efficiency and obvious advantages.